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Invertibility of Boolean control networks with applications to biological systems

来源: 发布时间: 2019-09-04 点击量:
  • 讲座人: Kuize Zhang
  • 讲座日期: 2019-09-05
  • 讲座时间: 10:30
  • 地点: 长安校区 文津楼数学与信息科学学院学术交流厅

讲座内容简介:
Invertibility is an interesting and classical control-theoretic problem, which implies that the input sequence of a control system can be determined by the output sequence. We adopted the theory of symbolic dynamics to characterize it for Boolean control networks (BCNs). First, it was shown that a BCN generates a continuous mapping from the space of infinite input sequences to the space of infinite output sequences. Based on it, the concept of invertibility of BCNs was defined by the bijectivity of the mapping. Second, using the theory of symbolic dynamics, an equivalent test criterion for invertibility was given; and then an algorithm to construct the inverse BCN for an invertible BCN based on the semi-tensor product of matrices was designed. Third, as an application of invertibility to systems biology, it was proved that the BCN model proposed by Fauré et al. (2006) is not invertible, i.e., arbitrarily controlling mammalian cell cycles is unfeasible, at the theoretical level.

讲座人简介:
Kuize Zhang received the B.S. and Ph.D. degrees in Mathematics and Systems Engineering from Harbin Engineering University, China, in 2009 and 2014, respectively. He held visiting positions at University of Turku, Finland (Sep. 2012-- Sep. 2013), and the Chinese Academy of Sciences (Jan. -- Oct., 2015). He was a project officer of Nanyang Technological University, Singapore (Oct. 2013 -- Oct. 2014), postdoc at Chinese Academy of Sciences (Nov. 2015 -- Nov. 2017), and postdoc at Technical University of Munich (Sep. 2016 -- Aug. 2017). He has been a postdoc at KTH Royal Institute of Technology, Sweden, since Sep. 2017.
His current research interests include formal methods, Boolean networks, discrete event systems, etc. He has published over 20 journal papers and 20 conference papers, and also published 1 monograph. Dr. Zhang is a Senior Member of IEEE (2017-present), received the 2016 Chinese Association of Automation (CAA) Outstanding Doctoral Thesis Nomination Award, and the Humboldt Research Fellowship in 2019.

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